July 01, 2009

2009 Summer Series - Inhalation Technology Podcast

Back for another year the CIMIT Summer Education Series 2009 is here. Every Tuesday in July at 4:00pm we will be at MIT discussing the newest and most exciting areas in Inhalation Technology.

This week Lynn sat down with two parts of the trifecta making up our Inhalation Technology Program, Dr. Jose Venegas and Dr. Jussi Saukkonen. In just over five minutes we hear how Inhalation Technology is playing a big role in treatment for TBI/PTSD, the challenges of our own breathing, and how students can get involved.



For more information on attending our free Summer Series please click here


We have some tremendous topics and speakers this year and I hope you'll read more about them here.

  • July 7, 2009 - Inhalation Technology Fundamentals
  • July 14, 2009: Treatment of Respiratory Diseases
  • July 21, 2009: Role of Inhalation Technologies for Organ Protection and Patient Sedation in Critical Care
  • July 28, 2009: Future of Inhalation Technology

And we'll see you at The Forum!

CIMIT - Center For Integration of Medicine and Innovative Technology

June 01, 2009

Why a 'Free Ferrari' Makes for Bad Healthcare in the Developing World

6-novitec-ferrari-f430
Where does the Developed World meet the Developing world?

If someone gave you a free Ferrari, you would probably take it. Who wouldn’t? A $230,000 ride for free is not too bad of a deal. But consider this, after you drive that Ferrari just 30,000 miles you will probably have spent upwards of $60,000 just to keep it on the road. And that doesn’t even include the insurance. So now, that free ride doesn’t sound so great anymore and you’re stuck taking the bus.

The same applies to healthcare in the developing world. When poor countries receive neonatal incubator donations from huge medical companies (and that happens all the time), they don’t come with a mechanic, tools, replacement parts or a warranty. So when that expensive $200,000 incubator breaks down it ends up in the back yard – Rusting out.

An incubator in the developing world is only as good as the infrastructure there to deploy and maintain it correctly. Simply, the resources available in the developing world make most medical solutions from our world unsustainable.

Tim Prestero of Design that Matters talked to us a few weeks ago and walked us through his development process for the Car-Part Incubator and how he solved this problem. He tells us how a Toyota truck can save a babies life and keep working for years.

This project you will remember is part of CIMIT's Global Health Initiative headed up by Dr. Kris Olson, one of Scientific American's 10 for 2009.

Running Time: 10 Minutes



Center for Integration of Medicine and Innovative Technology (CIMIT)

May 19, 2009

Listening to your Patients for better Healthcare Podcast

This week we sat down with Dr. Ron Dixon and Dr. David Judge who have an obsession with listening to their patients. Those of you who are patients (that’s all of us) the idea of being listened to by your physician probably sounds refreshing. Ron and David are two physicians who want to help shape a new healthcare model that fits you by listening. They are pushing forward a healthcare delivery model that fits the realities of a patients life and the economy.

Dr. Judge tells us about his focus on developing a clinical space that is safe, effective and open to experimentation. You can’t design a more effective physical space for improved patient care without getting hands on and trying things out.  He tells us how you have to actually build the space for patient care and be flexible enough to adapt and disseminate what you learn.

Dr. Dixon tells us about why physicians getting paid to email their patients or webcast with them will lower the cost of healthcare overall and hopefully be a better fit for some.


We have an exciting Forum coming up and we hope you’ll join us by clicking here for more information

May 14, 2009

Small Things Move Quickly - Updates in Global Health

Last week Dr. Kris Olson and Aya Caldwell of the CIMIT Global Health Initiative gave us a view into their approach on solving neonatal asphyxia through sustainable training in the developing world. What I love about their work here is that they are not changing a culture or imposing new paradigms, instead they are local capacity building where the midwives themselves came up with their model of sustainability.

In short, Kris and Aya have helped midwives in Aceh Indonesia utilize a tool that already existed to them, but wasn't being implemented properly. Simple training and simple technology can now become a badge of honor. This was a big problem with a small solution and from their presentation one thing became very clear: Small things moves quickly.

A few key points to remember on this topic:

  • Birth asphyxia (failure to breathe) is the third leading cause of neonatal deaths worldwide (1 million deaths/year)
  • With proper resuscitation techniques 70-80% of these deaths can be averted
  • Midwives in many areas of Indonesia have not received any continuing medical education in 9 years due to the Tsunami and preceding civil conflict

In this 7 minute video Kris and Aya give us a breakdown as to how they did it and where they go from here.



Coming next: We'll be posting a stunning presentation by Tim Prestero of Design That Matters on the Car-Part Incubator. Look for it shortly!

Best,

Mike

April 29, 2009

For Sale: One Space Suit, slightly used (best offer)

NASApix03

For Sale: One Space Suit, slightly used (best offer)


BOSTON 29 April 2009 - NASA has an opportunity to explore the farthest reaches of space with capabilities far beyond their current reach if they abandon manned spaceflights and turn their attention completely to the development of robotics. This crucial change will simultaneously improve our lives here on Earth and could create a new economic goldmine for the U.S. 

Space exploration is one of the greatest and most important scientific undertakings humans have ever undertaken. The advances we have made in all areas of science and medicine cannot be overstated. However, there is a high cost to this exploration. 439 humans total have flown into space and twenty-two have been killed on spaceflights. If you then factor in space training deaths and ground personnel killed that total number jumps to 104 human deaths. It is painful to realize that sending 439 humans into orbit worldwide, we have suffered a 25% rate of death. To put that number into perspective for you: If we accepted the same level of risk on commercial airline flights as we do on spaceflights a staggering 1,250,000 people would die in a plane crash (or as the collateral of a plane crash) every single day.

Before you go thinking I’m one of those people who questions why we need NASA, I’m not. I love space, space exploration, and it is clear that space exploration has been the driving catalyst behind many of the most beneficial inventions of our time as well as a significant generator for jobs. We need NASA and space exploration now more than ever.

However, the days of sending manned missions into space is probably coming to an end. First, because it is too costly to the incredibly bright minds that we lose and that cannot be replaced. Second, because with our attention on human spaceflight, we undercut the crucial development of robotics, which has far greater potential in today’s changing world. And it is this second point on robotics that has real potential.

The potential advancements we would make engineering robotic spaceflights and missions would outweigh what we gain by manned spaceflight. We are, in effect, limited by our own bodies abilities and safety concerns. We are limited by the fact that our fingers are perfect at many tasks, and so the price we pay is that someone who has lost their fingers does not benefit from a robotic hand never engineered. We take for granted what our bodies can accomplish naturally as compared to what we can currently with robotics (commercial sector). I think many of us would agree that the study of the human heart in orbit should take a backseat to advancing robot assisted laparoscopic surgery in the heart here on Earth. To make that advancement space is the perfect problem/opportunity.

The challenge of sending robotics into space that will preform the same functions as a human will bring us to incredible new scientific achievements. If 100% of the money (currently over $10,000 per Lb in space), resources, efforts and collective intelligence of NASA were going into the development of robotics for unmanned spaceflights, I guarantee we would have far greater achievements in space exploration than today, but with the addition of rapid development in our healthcare, as well as other sectors, even the economy.

For healthcare we need robotics in our day-to-day from surgery, prosthetics, eldercare, medical education, infectious disease control and general healthcare. This growing worldwide need for robotics could be one of the next great economic stabilizers for the United States. Instead of making GM cars that struggle for a market, we could be producing a wide array of robotics for applications in manufacturing, transportation and energy production, all spun from space exploration. In World War II, we went from making cars to bomber aircraft in months, we could do the same here.

Finally, I couldn't write anything about robotics without some mention of projects like FIRST or Lego Mindstorms. With FIRST Dean Kamen and John Abele have done a tremendous service to the world. They have inspired young people from all walks of life to become engaged in participatory competitions focused on the development of robotics. They have created an entire generation of young people who  might not dream of being one of the 439 humans in space, but now have the very real dream of sending their robots as far as we have ever gone, accomplish what we never have. When these student competitors make their way through higher education and into the workplace they will be looking for some place to use their robotics skills. These young people will spearhead in new markets, companies and products. We would all be wise to start preparing for that shift now.

Bottom line, we are not trying to colonizing another planet, instead we are focused on improving upon our own. Yes, I would miss the image of humans in space, it holds a special place within all of us, but I have to think of the better outcomes possible. Lets use robotic space missions as the catalyst for a new age and a great leap in our everyday lives.

Best,

Mike


CIMIT blog is a part of The Center for Integration of Medicine and Innovative Technology - CIMIT.org

April 21, 2009

The New Economic Playbook for Healthcare

In the Spring of 2008 Zen Chu (Accelerated Medical Ventures) gave what became a groundbreaking presentation and discussion on Venture Capital in Medicine.

Last week, we revisited the subject of VC in Healthcare with Zen, but this time with the aim of talking about the new age. Clearly, the playbook has changed in recent months since the economic slowdown, and to tackle the topic Zen brought along Michael Greeley (Flybridge Capital Partners), Elazer Edelman, MD, PhD (Harvard Medical School/Highland Capital), Joe Smith, MD, PhD (VP, Emerging Technologies, Johnson & Johnson) and Marsha Moses, PhD (Children's Hospital Boston, Harvard Medical School).

What Zen and his crew have brought us is another fundamentally important set of talks that hit home for everyone involved with healthcare.

Zen introduces the healthcare innovation landscape, funding sources for R&D and commercialization, major value drivers and funding milestones. He also describes teams needed for medical ventures and roles for physicians from invention through clinical trials - running time: 7 minutes

Here are the New Playbook for Healthcare Innovation presentation slides, including some not shown in the video. Zen Chu's popular presentation High Impact Clinical Innovation: Strategies and Techniques are also linked below.


Next, we launch into the panel discussion where Michael Greeley wants to know about the realities of today’s economic situation - running time: 7 minutes


The panel then explores the capital gap, a lack of liquidity in the markets, and how to navigate to continue developing companiesrunning time: 10 minutes


Then the panel covers the checklist for investment, how parameters for investment have changed, and how to clear early hurdlesrunning time: 13 minutes


Finally, we take questions form the audience, which cover: setting the bar in medicine, global influence/innovation, realities of bootstrapping, early stage seed money, SBIR’s, and physician adoption/culturerunning time: 20 minutes


Material for reference: You can see last years presentation slides here, the video here or you can also see Michael Greeley's VC Panel video here

Speakers: ZEN CHU (Accelerated Medical Ventures) . ELAZER EDELMAN, MD, PhD (MIT / HST / Harvard Medical School / Highland Capital) . MICHAEL GREELEY (Flybridge Capital Partners) . MARSHA MOSES, PhD (Children's Hospital Boston, Harvard Medical School) . JOE SMITH, MD, PhD (VP, Emerging Technologies, Johnson & Johnson COSAT)

April 08, 2009

The New Playbook for Healthcare Innovation

BOSTON, April 08, 2009 - Next Tuesday (April 14, 2009) Zen Chu and CIMIT are holding a Forum on the realities of Healthcare Venture Capitalism in today's economic climate and how to reconcile that with exciting new technologies. If you're a physician, a clinician or an engineer and have been struggling to get practical advice or tangible lessons on commercializing a product/technology in a 2.0 world, this is the forum.

Zen is a CIMIT All-Star VC how knows the in and out of the new playbook for Innovation. Zen has brought together ELAZER EDELMAN, JOSEPH SMITH, MICHAEL GREELEY to give presentations and a panel discussion.

We spoke with Zen and Michael for a couple minutes the other day about what is going on in the Healthcare space for VC's. Listen in to the Podcast below.

As always the CIMIT Forum is free and open to all, every Tuesday. April 14th, 2009 we will be at the Simches Center at MGH. Click here for more information.

 

Why You Shouldn't Cancel Your Conference Because of the Economy

Scared of this happening?

conference

BOSTON, April 08, 2009 - Every Fall as the leaves in New England begin to turn the city of Boston comes alive intellectually. Great minds in medicine and business from all over the world converge on the city for the annual medical conference season and the streets crest with fresh ideas, excitement and even… hope. Of course most of this goes unnoticed by the everyday person, but to those in the epicenter of medicine, the energy is profound.

This year, things will likely be somewhat muted by the economic environment. In downturn economies many companies first cut is in travel and thus cut back on conferences. This in turn causes many organizations to drastically rethink their annual conferences due to lowered attendance, but it is more important now than ever to avoid this trap.

While we should all be safeguarding our outreach with social networks and new media, there is still value to attracting great minds to your organization with your conference. A few key points to remember:

   • Canceling your annual meeting could be seen as a sign of instability

   • Your conference is opt-in marketing and steady branding for your organization

   • Your conference is business development all year long (without cold calling)

   • Good conferences create good content for social media

   • Leverage your keynote speakers and faculty to strengthen yourself online

Here at CIMIT our annual Innovation Congress has become a hot new cornerstone within the field of innovation in medical devices on the battlefield and at home. Our programs in Medical Simulation, NOTES, Global Health, Traumatic Brain Injury, and PTSD are key pivot points for our future. One of the most immediate ways to attract attention to our new programs from scientists, engineers, VC’s and private industry is with our conference where people get hands on and interface directly. 

And while it is important to remember that this year it might be hard to make money on a conference, you can still save your gross margin with a budget neutral conference based on sponsorship.

For more information on the CIMIT Innovation Congress 2009 please click here

March 16, 2009

Microfludics Revisited Podcast

I had the opportunity to talk with Dr. Virna Sales and Dr. Catherine Klapperich on the topic of their upcoming CIMIT Forum on Microfluidics. I feel like every singe day I'm hearing more about the possibilities of Microfluidics in medicine and what is really getting me excited is that results are showing and data is firm. In addition, other disciplines of science have started to find application for these technologies and there is a strong focus on making these new advances sustainable and small.


Very exciting. For more information on the free weekly CIMIT forum please click here

And we'll see you at the forum!




March 12, 2009

Stem Cell Biology & Cell-Rolling Technique

Micro-environmental Regulation of Stem Cells

David Scadden, MD, Gerald and Darlene Jordan Professor of Medicine, Harvard University; Co-Director, Harvard Stem Cell Institute; Co-Chair; Department of Stem Cell and Regenerative Biology, Harvard University; Director, Center for Regenerative Medicine, Massachusetts General Hospital, dscadden@partners.org 
Moderator: Charles A. Vacanti, MD, Anesthesiologist-in-Chief, Leroy D. Vandam/Benjamin G. Covino Professor of Anaesthesia, Harvard Medical School; Director, Laboratories for Tissue Engineering and Regenerative Medicine, Brigham and Women's Hospital, cvacanti@partners.org  
 
 
 
David Scadden will help us explore the regulation of stem cells by their microenvironment focusing on the hematopoietic system as a model. Deconstructing the elements of a naturally occurring niche will be discussed and how that information can be used in developing therapeutics will be presented. Finally, a word of caution will be introduced by an example of how a dysfunctional niche can lead to neoplasia.  

Nudging Cells Using Molecular Interactions: Towards Label-free Cell Rolling Separation

Rohit Karnik, PhD, d’Arbeloff Assistant Professor, Department of Mechanical Engineering, Massachusetts Institute of Technology, karnik@mit.edu 
Moderator: Jeffrey Borenstein, PhD, Distinguished Member of the Technical Staff at the Charles Stark Draper Laboratory; Co-Program Leader, Tissue Engineering, CIMIT, jborenstein@draper.com 
 
 
Separation of cells using surface receptors typically relies on labeling with fluorescent dyes or magnetic beads, or capture on surfaces. While these approaches are extremely useful, it is desirable to minimize sample processing for point-of-care diagnostics and for therapeutic purposes. Rohit Karnik's lab is exploring a new method for label-free cell separation. This approach is based on the team's discovery that asymmetrically patterned receptor edges have the ability to nudge cells flowing over the patterns so that they travel at an angle to the direction of fluid flow. This effect relies on transient adhesive interactions that typically occur during cell rolling, a physiological phenomenon exhibited by various cell types including leukocytes, cancer cells and stem cells. As the cell rolls on a surface in a fluid flow, bonds are formed at the leading edge of the cell and are broken at the trailing edge. Combining cell rolling with asymmetric receptor patterning enables control of the trajectories of the rolling cells, and opens the possibility for label-free cell separation where a stream of cells could be separated and collected in a continuous-flow manner in a simple device with minimal to no sample processing. Dr. Karnik will present results with rolling of HL-60 cells on patterned P-selectin receptors. He will also discuss progress on using this edge effect to realize a microfluidic device to separate cells and our efforts on modeling of the cell rolling phenomenon. Future development of this technology may lead to simple, label-free methods for detection of systemic inflammation, blood counts, isolation of cancer cells, and fractionation of stem cells.